Dihydrogen driven cofactor recycling for use in bio-catalysed asymmetric organic synthesis

Thesis

Asymmetric reductions are used to produce chiral molecules, which are important precursors for the pharmaceutical industry. Bio catalytic reductions often display high enantioselectivity without the cost and toxicity associated with metal catalysis. However, unlike metal catalysts which use H₂ directly, many useful redox-enzymes require the hydride donor NADH. NADH is expensive; therefore for a bio-catalytic process to be viable it must be recycled, usually by using a sacrificia...

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Authors: Lonsdale, T

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Biocatalysis; Electrochemistry; H2 Driven Catalysis; Enzymes; Cofactor recycling; Catalysis
• Subjects: Chemistry, Inorganic