Thesis
Germline determinants of colorectal cancer risk and outcome
- Abstract:
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Colorectal cancer (CRC) is the third most common global cancer. Approximately one fifth of phenotypic variance in CRC is attributable to additive genetic inputs: the disease risk is heritable. The nature and location of these genetic inputs has been the preoccupation of association studies over the last decade. Variation at some 30 genomic loci influences sporadic CRC risk. However, in Mendelian disorders this risk is almost absolute. Such cancer syndromes include Lynch syndrome, caus...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
-
uuid:a03ce112-cece-49ac-8843-247d84ec6854
- Deposit date:
- 2018-03-04
Terms of use
- Copyright holder:
- Freeman-Mills, L
- Copyright date:
- 2017
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