Thesis

Fertility preservation in pre-pubertal boys with cancer: a three-dimensional (3D) prepubertal testicular organoid culture system for in vitro spermatogonial stem cell (SSCs) propagation and spermatogenesis

Abstract:: The overall survival rate of childhood cancer has increased over the last decades due to improvements in cancer therapies. However, aggressive cancer treatments, such as chemo- or radiotherapy, can leave young prepubertal boys infertile. Cryogenically ‘banking’ sperm from prepubertal boys is impossible because spermatogonial stem cells (SSCs) only start to produce sperm after puberty. Thus, to help these patients preserve their fertility, it is recommended to cryopreserve their immature testi...
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APA Style

Tang, S. (2022). Fertility preservation in pre-pubertal boys with cancer: a three-dimensional (3D) prepubertal testicular organoid culture system for in vitro spermatogonial stem cell (SSCs) propagation and spermatogenesis [PhD thesis]. University of Oxford.

MLA Style

Tang, S. Fertility Preservation in Pre-Pubertal Boys with Cancer: a Three-Dimensional (3D) Prepubertal Testicular Organoid Culture System for in Vitro Spermatogonial Stem Cell (SSCs) Propagation and Spermatogenesis. 2022. University of Oxford, PhD thesis.

Chicago Style

Tang, S. 2022. “Fertility Preservation in Pre-Pubertal Boys with Cancer: a Three-Dimensional (3D) Prepubertal Testicular Organoid Culture System for in Vitro Spermatogonial Stem Cell (SSCs) Propagation and Spermatogenesis.” PhD thesis, University of Oxford.
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Files:: Tang_2022_Fertility_preservation_in.pdf

(Preview, Dissemination version, pdf, 84.8MB, Terms of use)

Authors

+ Tang, S More by this author

Division:: MSD
Department:: Women's & Reproductive Health
Role:: Author

Contributors

Role:: Supervisor

Role:: Supervisor
ORCID:: 0000-0001-9229-7216

+ Clarendon Fund More from this funder

Funder identifier:: http://dx.doi.org/10.13039/501100014748
Funding agency for:: Tang, S
Programme:: Clarendon Scholarship, University of Oxford

DOI:: 10.5287/ora-mp6yy579o
Type of award:: DPhil
Level of award:: Doctoral
Awarding institution:: University of Oxford

Language:: English
Keywords:: testicular organoids

immature testicular tissues

three-dimensional

transportation time

vitrification
Subjects:: Fertility preservation
Pubs id:: 2268955
Local pid:: pubs:2268955
Deposit date:: 2022-08-04
ARK identifier:: ark:/29072/ora_9f7f4644481549e396fc1487821932c5

Terms of use

Copyright holder:: Shiyan Tang
Copyright date:: 2022

Licence:: CC Attribution-NonCommercial (CC BY-NC)

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