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Thesis

Mechanistic insights on protein aggregation and phase separation

Abstract:

Proteins are essential structural and functional components of cells and act at a range of assembly states, from single proteins to macromolecular complexes. The pathological aggregation of proteins into amyloid fibrils and other morphologies of aggregates is a hallmark of several human diseases, many of which are neurodegenerative disorders like Alzheimer’s and Parkinson’s and pose a global health burden due the limited therapeutic approaches.


Proteins carry out their function...

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Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Research group:
Baldwin
Oxford college:
St Anne's College
Role:
Author
ORCID:
0000-0003-0892-6433

Contributors

Institution:
Eli Lilly
Role:
Contributor, Supervisor
Institution:
Eli Lilly
Role:
Contributor, Supervisor
Institution:
Eli Lilly
Role:
Contributor
Institution:
Eli Lilly
Role:
Contributor
Institution:
Eli Lilly
Role:
Contributor
More from this funder
Name:
European Research Council
Funder identifier:
https://ror.org/0472cxd90
Funding agency for:
Casablancas Antràs, V
Grant:
101002859
Programme:
European Union’s Horizon 2020 Research and Innovation Programme
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Name:
Engineering and Physical Sciences Research Council
Funder identifier:
https://ror.org/0439y7842
Funding agency for:
Casablancas Antràs, V
Grant:
EP/L016044/1
Programme:
EPSRC and MRC Centre for Doctoral Training in Systems Approaches to Biomedical Science
More from this funder
Name:
Eurofins (United Kingdom)
Funder identifier:
https://ror.org/03gmmtm59
Funding agency for:
Casablancas Antràs, V
Programme:
Eurofins Award
More from this funder
Name:
Eli Lilly (United Kingdom)
Funder identifier:
https://ror.org/00psab413
Funding agency for:
Casablancas Antràs, V
More from this funder
Name:
COVID-19 Scholarship Extensions Fund (CSEF)
Funding agency for:
Casablancas Antràs, V
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:

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