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Thesis

Development of human iPSC-derived 3D cortical constructs for repair of traumatic brain injury

Abstract:

Traumatic brain injury (TBI) causes neuronal loss and disruption of cortical circuitry, and current therapeutic strategies remain limited. Cell-based approaches hold promise, yet repairing the cerebral cortex is particularly challenging due to its complex structural and functional organisation. I hypothesised that, following TBI, implantation of 3D neuronal constructs derived from temporally specified early and late neuronal progenitor cells (ENPCs and LNPCs) can enhance implant survival and ...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy and Genetics
Oxford college:
St John's College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy and Genetics
Role:
Supervisor
ORCID:
0000-0002-6852-6004
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy and Genetics
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy and Genetics
Role:
Supervisor
ORCID:
0000-0002-9945-9473

DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Title:
Development of human iPSC-derived 3D cortical constructs for repair of traumatic brain injury
DOI:
10.5287/ora-jbpzeom0p-2 Request object version
Created date:
2026-01-27

Title:
Development of human iPSC-derived 3D cortical constructs for repair of traumatic brain injury
DOI:
10.5287/ora-jbpzeom0p-1 Request object version
Created date:
2026-01-27

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