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Thesis

Targeted cell-type specific gene expression profiling in a transgenic mouse model of Parkinson’s

Abstract:

Parkinson's disease is a neurodegenerative disorder that is pathologically characterised by the preferential cell death of vulnerable dopaminergic neurons (DAn) in the midbrain. Multiplications of the human alpha-Synuclein (aSyn) gene locus give rise to autosomal-dominant Parkinson’s and elevated aSyn expression has been linked to an increased risk to develop sporadic Parkinson's. Thus, aSyn provides an important link between familial and sporadic forms of the disease. This thesis brings t...

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Department:
Physiology, Anatomy & Genetics
Role:
Author, Copyright Holder

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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