Thesis
Autoinhibition releasing provides a platform for developing p21-activated kinase-1 (PAK1) activators for hypertrophic heart diseases
- Abstract:
-
Kinase activators have attracted great attention in recent years due to their therapeutic benefits in pathological conditions. However, the pursuit of kinase activators has encountered limited success, emphasising the importance of a strategic approach to define specific targeted sites. Our focus centres on p21activated kinase-1 (PAK1), which is important in maintaining cellular homeostasis and enhancing cardiomyocyte adaptability to stress. Numerous studies have highlighted the therapeuti...
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Authors
Contributors
+ Lei, M
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Role:
- Supervisor
- ORCID:
- 0000-0002-0928-341X
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Deposit date:
-
2025-01-21
Terms of use
- Copyright holder:
- He, Y
- Copyright date:
- 2023
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