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Thesis

Development of novel hyperpolarized magnetic resonance techniques for metabolic imaging of the heart

Abstract:

The advent of hyperpolarized magnetic resonance (MR) has provided new potential for real-time visualization of in vivo metabolic processes. The aim of the work in this thesis was to use hyperpolarized substrates to study rapid metabolic processes occurring in the healthy and diseased rat heart. Initial work, described in Chapter 2, optimized the hyperpolarization process to reproducibly generate tracers. Chapter 3 describes use of hyperpolarized 1-13C-pyruvate to investigate in vivo flux thro...

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Institution:
University of Oxford
Research group:
Cardiac Metabolism Research Group
Oxford college:
Lincoln College
Department:
Medical Sciences Division - Sherrington Building,Le Gros Clark Building

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2009
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:9c5b6638-c71e-4eec-835b-e2cea3b9106e
Local pid:
ora:2776

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