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Glucosamine Synthetase in the Human Gastrointestinal Mucosa in Health and Disease

Abstract:

Glucosamine synthetase (L-glutamine-D-fructose-6-phosphate amino-transferase, EC.2.6.1.16) is the cytoplasmic enzyme which catalyses the synthesis of glucosamine-6-phosphate from fructose-6-phosphate and glutamine. It is a rate-limiting step in the biosynthesis of UDP-N-acetyl-glucosamine and probably also of gastrointestinal mucus, which is glycoprotein in composition. Glycoproteins consist of a protein backbone on which are assembled complex carbohydrate side-chains. The first sugar to b...

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Peer review status:
Peer Reviewed

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Department:
University of Oxford
Role:
Author
This thesis was digitised thanks to the generosity of Dr Leonard Polonsky More from this funder
Publication date:
1975
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Local pid:
polonsky:7:38

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