Thesis
Investigating the endoplasmic reticulum unfolded protein response and its role in sleep
- Abstract:
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Proteostasis involves regulating the synthesis, folding and quality control of proteins in the cell, and is essential for all cells in our body, including neurons in our brain. Errors in protein folding are dealt with by quality control mechanisms in the cell. One such mechanism is the Unfolded Protein Response (UPR), which is elicited by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) under conditions of ER stress. The UPR is an adaptive process involved in maintai...
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- Files:
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(Preview, Dissemination version, pdf, 49.9MB, Terms of use)
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Authors
Contributors
+ Akerman, C
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Role:
- Supervisor
+ Vyazovskiy, VV
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy & Genetics
- Role:
- Supervisor
- ORCID:
- 0000-0002-4336-6681
+ Newey, S
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Role:
- Supervisor
+ Christianson, J
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDORMS
- Role:
- Examiner
- ORCID:
- 0000-0002-0474-1207
+ Biotechnology and Biological Sciences Research Council
More from this funder
- Grant:
- BB/S007938/1
- Programme:
- BBSRC Interdisciplinary Bioscience Doctoral Training Programme
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
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2024-07-03
- ARK identifier:
Terms of use
- Copyright holder:
- Chakrabarty, A
- Copyright date:
- 2023
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