Thesis
Deep molecular profiling of the anti-tumour immune response in immune checkpoint inhibitor-treated oesophageal cancer
- Abstract:
-
Combined immune checkpoint inhibitors (ICI) with chemotherapy in advanced oesophageal cancer (OC) has shown survival benefit in phase III studies, resulting in ICI’s recent approval to treat advanced OC. The role of ICI in peri-operative OC is debated, and large clinical studies are ongoing. Patients’ response to ICI is variable and it is unclear what underlies this heterogeneity. To address this challenge, 38 metastatic and 35 operable OC patients were enrolled to receive ICI in the LUD20...
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Authors
Contributors
+ Lu, X
- Institution:
- University of Oxford
- Division:
- MSD
- Role:
- Supervisor
+ Simmons, A
- Institution:
- University of Oxford
- Division:
- MSD
- Role:
- Supervisor
- ORCID:
- 0000-0003-3454-0710
+ Dustin, L
- Institution:
- University of Oxford
- Division:
- MSD
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Deposit date:
-
2025-05-02
- ARK identifier:
Terms of use
- Copyright holder:
- Hannah Sophie Fuchs
- Copyright date:
- 2024
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