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Thesis

Hippo tumour suppressor and Hedgehog pathway crosstalk at the primary cilia

Abstract:

Inappropriate activation of the Hedgehog signalling pathway is implicated in broad range of cancers, particularly basal cell carcinoma and medulloblastoma. Recent attempts to target Hedgehog signalling clinically have yielded mixed patient responses, highlighting the need for further study into Hedgehog pathway regulation. Vertebrate Hedgehog signalling occurs within, and is dependent on, the primary cilia. The function of a critical negative regulator of Hedgehog signalling, Suppressor of...

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Supervisor
Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford

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