Thesis icon

Thesis

Role pf PPARalpha in the cardiac metabolic adaptation to chronic hypoxia

Abstract:

The principal substrate used by the normal adult human heart is free fatty acids, the remainder being, predominantly,carbohydrate. During failure, the heart becomes less reliant on fatty acid metabolism, possibly as a result of tissue hypoxia. Therefore, understanding hypoxic adaptation may explain the metabolic changes that occur during the development of heart failure.As peroxisome proliferator activated receptor alpha (PPARα) modulates cardiac fatty acid metabolism, the work in this the...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Research group:
Cardiac Metabolism Research Group
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:97e40889-8ae6-47db-867c-f1b020959a90
Local pid:
ora:7121
Language:
English
Keywords:
Subjects:

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP