Thesis
Characterisation of KEAP1 as a novel factor in DNA base damage repair and investigation of its relationship with PARPs
- Abstract:
-
Genomes are constantly subjected to various genotoxic stresses that can cause DNA damage, which, if unrepaired, can lead to cancer or cell death. To counteract this threat, cells have evolved a network of pathways that resolve DNA damage, termed DNA damage response (DDR). These crucial pathways and the interactions between them are regulated by post-translational modifications, including poly(ADP- ribosyl)ation, which is carried out by poly(ADP-ribose) polymerases (PARPs). PARP1 and PARP2 ...
Expand abstract
Actions
Authors
Contributors
+ Ronson, G
Role:
Contributor
+ Lakin, N
Role:
Supervisor
+ McHugh, P
Role:
Examiner
ORCID:
0000-0002-8679-4627
+ Higgs, M
Role:
Examiner
Funding
+ Medical Research Council
More from this funder
Funder identifier:
https://ror.org/03x94j517
Grant:
1958771
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- DOI:
Item Description
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2024-02-09
Terms of use
- Copyright holder:
- Jagoda Janina Rokicka
- Copyright date:
- 2023
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record