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Thesis

The role of LYVE-1 in macrophages during heart regeneration and repair

Abstract:

Myocardial infarction (MI) causes substantial cardiomyocyte death and leads to heart failure, one of the most common causes of death globally. While surgical and transcatheter techniques have evolved to facilitate reperfusion, loss of these cardiomyocytes remains irreversible in humans. This cell death is accompanied by significant infiltration of immune cells which are required to clear the necrotic debris. In adult mice, MI activates the cardiac lymphatics, which undergo sprouting angiogene...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy and Genetics
Sub department:
IDRM (DPAG)
Research group:
Riley Group
Oxford college:
Balliol College
Role:
Author
ORCID:
0000-0002-8020-0197

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy and Genetics
Sub department:
IDRM (DPAG)
Oxford college:
Jesus College
Role:
Supervisor
ORCID:
0000-0002-9862-7332
Institution:
School of Cardiovascular & Metabolic Medicine & Sciences, King’s College London, London, UK
Role:
Supervisor
ORCID:
0000-0003-2023-6304
Institution:
University of Oxford
Division:
MSD
Department:
Radcliffe Department of Medicine
Sub department:
RDM-Division of Cardiovascular Medicine
Oxford college:
Pembroke College
Role:
Examiner
ORCID:
0000-0003-4118-1568
Institution:
European Institute for Molecular Imaging (EIMI), University of Münster, 48149, Münster, Germany
Role:
Examiner
ORCID:
0000-0002-3002-8237

DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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