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Thesis

Asymmetry of hippocampal function in mice: left-right differences in memory processing and vulnerability to amyloid beta

Abstract:

Amyloid beta (ABeta) and tau protein are both implicated in memory impairment in early Alzheimer’s disease, but whether and how they interact to cause synaptic dysfunction are unknown. Consequently, I firstly investigated whether tau protein is required for the robust phenomenon of ABeta-induced impairment of hippocampal long-term potentiation (LTP), a widely accepted cellular model of memory. I demonstrate that the absence of tau prevents the ABeta-induced impairment of LTP; moreover, a s...

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Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Oxford college:
Magdalen College
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Funding agency for:
OXION
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Funding agency for:
OXION
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral

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