Thesis
Investigating macrophage-lymphatic vessel interactions in neonatal mouse model of heart regeneration
- Abstract:
-
Myocardial infarction (MI) triggers an immune response, whereby phagocytic cells remove dead tissue and assist with the subsequent remodelling and repair of the infarcted heart. In adult mice, MI activates cardiac lymphatics, which function to drain the build-up of interstitial fluid (oedema) and traffic macrophages to mediastinal lymph nodes (MLNs), reducing inflammatory/fibrotic cell content and improving cardiac output. Mice at postnatal day 1 (P1) fully regenerate their heart following...
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Authors
Contributors
+ Pezzolla, D
- Role:
- Contributor
- ORCID:
- 0000-0001-8060-3706
+ De Villiers, C
- Role:
- Contributor
+ Rohling, M
- Role:
- Contributor
+ Kalisch-Smith, J
- Role:
- Contributor
+ Carr, C
- Role:
- Contributor
- ORCID:
- 0000-0003-0102-5261
+ Wellcome Trust
More from this funder
- Funder identifier:
- http://dx.doi.org/10.13039/100010269
- Funding agency for:
- Klaourakis, K
- Grant:
- 215103/Z/18/Z
- Programme:
- Wellcome Trust Four-year PhD Studentships in Science
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2022-03-06
Terms of use
- Copyright holder:
- Klaourakis, K
- Copyright date:
- 2021
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