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Thesis

Investigating macrophage-lymphatic vessel interactions in neonatal mouse model of heart regeneration

Abstract:

Myocardial infarction (MI) triggers an immune response, whereby phagocytic cells remove dead tissue and assist with the subsequent remodelling and repair of the infarcted heart. In adult mice, MI activates cardiac lymphatics, which function to drain the build-up of interstitial fluid (oedema) and traffic macrophages to mediastinal lymph nodes (MLNs), reducing inflammatory/fibrotic cell content and improving cardiac output. Mice at postnatal day 1 (P1) fully regenerate their heart following...

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Division:
MSD
Role:
Author

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Contributor
ORCID:
0000-0001-8060-3706
Role:
Contributor
Role:
Contributor
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Contributor
Role:
Contributor
ORCID:
0000-0003-0102-5261
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Name:
Wellcome Trust
Funder identifier:
http://dx.doi.org/10.13039/100010269
Funding agency for:
Klaourakis, K
Grant:
215103/Z/18/Z
Programme:
Wellcome Trust Four-year PhD Studentships in Science
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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