The developmental and evolutionary roles of isoforms of regulator of G protein signalling 3 in neuronal differentiation

Thesis

Fundamental to the complexity of the nervous system is the precise regulation in space and time of the production, maturation, and migration of neurons in the developing embryo. This is eloquently seen in the forming cranial sensory ganglia (CSG) of the peripheral nervous system. Placodes, which are transient pseudostratified neuroepithelia in the surface ectoderm of the embryo, are responsible for generating most of the neurons of the CSG. Placodal progenitors commit to the neuronal fa...

Expand abstract

Authors: Fleenor, S

• Publication date: 2014
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: evolution and development; isoform; regulator of g protein signalling 3; placode; neuronal migration; neuronal differentiation; neurogenesis
• Subjects: Biology; Evolution (zoology); Biochemistry; Genetics (life sciences); Development (zoology); Physiology and anatomy