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Thesis

Altered function of CCK-positive interneurons in mice over-expressing the schizophrenia risk gene neuregulin 1

Abstract:

The Neuregulin 1 (NRG1)-ErbB4 signalling pathway is implicated in critical processes for the development and function of neuronal circuits. Post mortem studies have reported that elevated expression of NRG1 type 1 isoform is associated with schizophrenia. Importantly previous behavioural studies in mice that overexpress the NRG1 type 1 isoform (NRG1tg-type-I) have suggested a schizophrenia endophenotype including impairment in the hippocampus-dependent spatial working memory, pr...

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Division:
MSD
Department:
Pharmacology
Department:
Department of Pharmacology
Role:
Author

Contributors

Department:
Department of Pharmacology
Role:
Supervisor
Department:
Department of Pharmacology
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:929fc588-5d12-4d52-a2ff-24be6765f747
Deposit date:
2018-01-21

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