A core outcome measurement set (COMS) for research and clinical practice in post COVID-19 condition (long COVID) in adults: an International Delphi Consensus study

Gorst, SL; Seylanova, N; Harman, N; O'Hara, M; Terwee, CB; Williamson, PR; Needham, DM; Munblit, D; Nicholson, T; Group, P-CS

Preprint

A core outcome measurement set (COMS) for research and clinical practice in post COVID-19 condition (long COVID) in adults: an International Delphi Consensus study

Abstract:: Background: Agreement is lacking regarding which instruments should be used for measurement of a recently-agreed core outcome set (COS) for clinical practice and research in post COVID-19 condition, also known as Long COVID.

Methods: A rigorous multi-step consensus study was conducted, including a comprehensive literature review informing a three-round online modified Delphi process followed by an online consensus meeting to finalise measurement instruments for this COS, thereby developing a Core Outcome Measurement Set (COMS). 594 participants from 58 countries spanning six continents, participated in the consensus process.

Findings: Consensus was reached for including the 'modified MRC Dyspnea Scale' for measuring the 'Respiratory functioning, symptoms, and conditions' outcome in the COMS. Two outcome measures from the acute COVID-19 COMS were included in this post COVID-19 conditionCOMS, namely 'Time until death' (for the Survival outcome) and 'Recovery Scale for COVID-19' (for the Recovery outcome). Consensus, based on predefined criteria, was not reached for the other 9 outcomes of the COS. However, based on the study results, suggested measurement instruments are provided for 'Fatigue', 'Post-exertion symptoms'; 'Pain', 'Physical function', 'Work/occupational and study changes' and for 'Cardiovascular', 'Nervous system', 'Cognition' and 'Mental' functioning, symptoms and conditions.

Interpetation: This international COMS provides a framework for assessing post COVID-19 condition in global clinical research and practice settings. Further evaluation is warranted as new data emerges on the performance of measurement instruments for the COS for this new clinical condition.

Publication status:: Published

Peer review status:: Not peer reviewed

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APA Style

Gorst, S. L., Seylanova, N., Harman, N., O'Hara, M., Terwee, C. B., Williamson, P. R., Needham, D. M., Munblit, D., Nicholson, T., & Group, P.-C. S. (2023). A core outcome measurement set (COMS) for research and clinical practice in post COVID-19 condition (long COVID) in adults: an International Delphi Consensus study. SSRN.

MLA Style

Gorst, S. L., et al. A Core Outcome Measurement Set (COMS) for Research and Clinical Practice in Post COVID-19 Condition (Long COVID) in Adults: an International Delphi Consensus Study. SSRN, 2023.

Chicago Style

Gorst, SL, N Seylanova, N Harman, M O'Hara, CB Terwee, PR Williamson, DM Needham, D Munblit, T Nicholson, and P-CS Group. 2023. “A Core Outcome Measurement Set (COMS) for Research and Clinical Practice in Post COVID-19 Condition (Long COVID) in Adults: an International Delphi Consensus Study.” SSRN.
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