Thesis
Utilising high throughput screening techniques to identify small molecule activators of the epicardium
- Abstract:
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The epicardium, the mesothelial layer covering the surface of the heart, plays an essential role during heart development. Epicardium derived cells (EPDCs) contribute essential cardiovascular cell types including vascular smooth muscle, interstitial fibroblasts and cardiomyocytes via the process of epithelial to mesenchymal transition (EMT) and EPDC paracrine signalling is critical for proper organ formation.
Whilst dormant in the adult heart, the epicardium is reactivated in resp...
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(Preview, pdf, 53.7MB, Terms of use)
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Authors
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- UUID:
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uuid:91626bb6-ab57-4c51-ade2-ef3d95c518d7
- Deposit date:
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2018-02-04
- ARK identifier:
Terms of use
- Copyright holder:
- Clunie-O'Connor, C
- Copyright date:
- 2017
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