Thesis
A novel two-ligand system for investigation of signal integration by non-catalytic tyrosine-phosphorylated receptors
- Alternative title:
- Use of a generic cellular system to analyse PD-1-mediated inhibition of T cell receptor signalling
- Abstract:
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Appropriate immune responses require integration of a variety of activating, coinhibitory, and co-stimulatory signals from cell surface receptors. One important class of immune receptors are the non-catalytic tyrosine-phosphorylated receptors (NTRs), a group of over 100 receptors, such as PD-1, CTLA-4, CD28, and the T and B cell antigen receptors. These receptors have a number of shared features that we propose have a functional significance, such as relatively small receptor-ligand dimens...
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- Files:
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(Preview, pdf, 39.8MB, Terms of use)
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Authors
Contributors
+ van der Merwe, P
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pathology Dunn School
- Role:
- Supervisor
+ Goyette, J
- Department:
- University of New South Wales
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- UUID:
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uuid:910f605d-3d7e-4a2c-a33a-d380d9702029
- Deposit date:
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2017-06-08
- ARK identifier:
Terms of use
- Copyright holder:
- Paterson, R
- Copyright date:
- 2016
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