Thesis
Improving HLA-E peptide complexes for low affinity peptides for development of HLA-E specific therapeutics
- Abstract:
-
MHC-E (HLA-E in human, Mamu-E in rhesus macaques) is a nonpolymorphic MHC class Ib molecule, with a species conserved evolutionary function that relates to NK-mediated monitoring of cellular homeostasis. This function relies on MHC-E presenting classical MHC class I leader sequence peptides VL9 (VMAPRT[L/V][V/L/I/F]L) in humans to NK cells, with recognition mediated by inhibitory NKG2A-CD94 and activating NKG2C-CD94 receptor engagement. The inhibitory signal mediated by NKG2A-CD94 engagement ...
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Authors
Contributors
+ Gillespie, G
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Role:
- Supervisor
+ McMichael, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Awarding institution:
- University of Oxford
- Language:
-
English
- Deposit date:
-
2026-07-10
- ARK identifier:
Terms of use
- Copyright holder:
- Max Nathan Quastel
- Copyright date:
- 2025
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