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Using fast-scan cyclic voltammetry to investigate monoamine release in BAC transgenic rodent models of Parkinson's Disease

Abstract:

Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Nigrostriatal dopamine (DA) neurons are particularly susceptible to degeneration in PD, and the concomitant loss of DA signalling in the striatum is believed to underlie the motor symptoms of PD.

Transgenic rodent models expressing PD-related genes have previously revealed changes to DA synapse function as one of the earliest stages of PD progression, often preceding protein aggregation and cell death. ...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Pembroke College
Role:
Author

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Supervisor
Role:
Supervisor


Publication date:
2014
DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford


Language:
English
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UUID:
uuid:8f83c8b8-7800-4607-98b3-f4a7f6841716
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