Thesis
Using fast-scan cyclic voltammetry to investigate monoamine release in BAC transgenic rodent models of Parkinson's Disease
- Abstract:
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Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Nigrostriatal dopamine (DA) neurons are particularly susceptible to degeneration in PD, and the concomitant loss of DA signalling in the striatum is believed to underlie the motor symptoms of PD.
Transgenic rodent models expressing PD-related genes have previously revealed changes to DA synapse function as one of the earliest stages of PD progression, often preceding protein aggregation and cell death. ...
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Authors
+ Medical Research Council; Parkinson's Disease Society of the United Kingdom
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- Funding agency for:
- Potgieter, D
- Publication date:
- 2014
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
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uuid:8f83c8b8-7800-4607-98b3-f4a7f6841716
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- Copyright holder:
- Potgieter, D
- Copyright date:
- 2014
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