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Thesis

The role of Wee1 in the hypoxia-induced DNA damage response and its potential as a therapeutic target

Abstract:

The majority of tumours have a poor vasculature which results in low oxygen supply. This, coupled with the high oxygen demand often leads to regions of hypoxia. The physiological relevance of this includes resistance to radiotherapy and chemotherapy, as well as activation of specific signalling cascades. Chk1, a component of the DNA damage response, is activated in acute hypoxia even in the absence of DNA damage. Loss or inhibition of Chk1 sensitises cells to hypoxia/reoxygenation. Wee1 is...

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Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Research group:
Dr Ester Hammond
Oxford college:
Pembroke College
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
More from this funder
Funding agency for:
O'Brien, E
Grant:
C6515/A9321
Publication date:
2012
Type of award:
MSc
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:8eba90bc-6fd5-4834-8586-e907f4078da4
Local pid:
ora:12281
Deposit date:
2015-09-29

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