Thesis
The role of RREB1 in human pancreatic beta cell development and function
- Abstract:
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Human genetics can be used as a tool to gain insights into fundamental aspects of human development, physiology and pathophysiology. Genome-wide association studies have uncovered multiple independent signals which alter risk for type 2 diabetes (T2D) and influence related glycaemic traits at the RREB1 locus. Fine-mapping revealed that one of these signals is driven by a common coding variant rs9379084 (p.D1171N), highlighting RREB1 as the causal transcript. Little is known about the funct...
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- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- UUID:
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uuid:8e1dcecb-4def-4686-950e-93fb2c273eee
- Deposit date:
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2020-02-18
Terms of use
- Copyright holder:
- Mattis, KK
- Copyright date:
- 2019
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