Glycine receptor antibodies: pathogenic mechanisms and clinical corrlates

Thesis

Glycine receptor antibodies have been identified in a few patients with progressive encephalomyelitis with rigidity and myoclonus (PERM), a highly disabling disorder characterised by rigidity, spasm and brainstem symptomatology. The clinical characteristics of patients with glycine receptor antibodies have not yet been fully described and it is not clear whether GlyR-Abs are pathogenic or just an epiphenomenon.

This study examined the clinical features and immunotherapy responses of...

Expand abstract

Authors: Carvajal González, A

• Publication date: 2014
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: Animal model; Progressive Encephalomyelitis with Rigidity and Myoclonus; Glycine receptor; Autoantibody; Stiff person syndrome
• Subjects: Medical Sciences; Neurology; Neuroscience; Neuroimmunology