Thesis
Chemical probes for histone lysine demethylases
- Abstract:
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The primary objective of this DPhil research project was to develop selective and cell-active inhibitors of the histone lysine demethylase KDM2A, which could potentially lead to the discovery of a novel chemical probe. Chapter one of this thesis introduces the role of histone lysine demethylases (KDMs) in the epigenetic regulation of gene expression and discusses the value of chemical probes as tools to study these enzymes. Chapter two describes the synthesis of a library of indoline-based...
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Funding
+ Systems Approaches to Biomedical Sciences Centre for Doctoral Training
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Funding agency for:
Gerken, P
Grant:
EP/L016044/1
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:8d98e1d6-6a79-4fbc-a04b-776179225498
- Deposit date:
- 2017-10-08
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Terms of use
- Copyright holder:
- Gerken, P
- Copyright date:
- 2016
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