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Thesis

Chemical probes for histone lysine demethylases

Abstract:

The primary objective of this DPhil research project was to develop selective and cell-active inhibitors of the histone lysine demethylase KDM2A, which could potentially lead to the discovery of a novel chemical probe. Chapter one of this thesis introduces the role of histone lysine demethylases (KDMs) in the epigenetic regulation of gene expression and discusses the value of chemical probes as tools to study these enzymes. Chapter two describes the synthesis of a library of indoline-based...

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Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
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Name:
Systems Approaches to Biomedical Sciences Centre for Doctoral Training
Funding agency for:
Gerken, P
Grant:
EP/L016044/1
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:8d98e1d6-6a79-4fbc-a04b-776179225498
Deposit date:
2017-10-08

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