Thesis icon

Thesis

The role of calnexin, calreticulin and heavy chain glycosylation in MHC class I assembly

Abstract:

Class I heavy chain (HC) must assemble with β-microglobulin (β2m) and acquire optimal peptide in order to be presented to cytotoxic T cells (CTLs). Calnexin is involved in the initial folding of class I HC and subsequent assembly with β2m. Incorporation of "empty" or suboptimally loaded class I molecules into the multimolecular loading complex is essential for them to acquire optimal peptides. The loading complex consists of several cofactors: TAP, tapasin, ERp57 and calreticulin. The pre...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2002
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603838284
URN:
uuid:8d626bbd-4927-4a52-b892-461e968a1c96
Local pid:
td:603838284

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP