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Thesis

The role of p97 cofactors SPRTN and FAF1 in DNA replication

Abstract:

It is well known that cancer cells are loaded with excess proteins. To survive this proteotoxic crisis cancer cells rely heavily on the ubiquitin proteasome system (UPS). Valosin containing protein (VCP) or p97 has recently emerged as a central player of UPS. Moreover, p97 inhibitors were shown to possess potent anti-cancer properties. Owing to the essential function of p97, it can be assumed that general p97 inhibition will be equally toxic to surrounding normal tissues. Interestingl...

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Department:
oncology
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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