Thesis
Investigating cell lineage specific biosynthesis of tenascin-C during inflammation
- Abstract:
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The extracellular matrix (ECM) is a complex network of molecules secreted by cells, which is essential for providing structural support and facilitating cell processes including adhesion, migration and survival. Tenascin-C is an immunomodulatory ECM protein that exhibits limited expression in healthy tissues, but is transiently elevated at sites of tissue injury, and is persistently expressed in chronic inflammatory diseases and tumours. Alternative splicing of 9 of tenascin-C's fibronecti...
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- Files:
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(Preview, pdf, 10.6MB, Terms of use)
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Authors
Contributors
+ Midwood, K
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDORMS
- Sub department:
- Kennedy Institute for Rheumatology
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:8c7306d8-53cf-4131-a134-f74885e37cc9
- Deposit date:
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2018-06-02
- ARK identifier:
Terms of use
- Copyright holder:
- Giblin, S
- Copyright date:
- 2018
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