- Abstract:
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Purpose: LY294002, a promising drug for chemotherapy, suppresses the activity of Phosphatidylinositol 3-Kinase (PI3K) which is pivotal to a number of processes such as proliferation, metabolism, and apoptosis. The compound has, however, been seen to have very variable efficacy in vivo.
Methods: Proliferation and viability of two immortalized cells with divergent bioenergetic profiles was determined using crystal violet staining, and the 3-(...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.0MB)
-
- Publisher copy:
- 10.14319/ijcto.51.14
-
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- Publisher:
- International Journal of Cancer Therapy and Oncology Publisher's website
- Journal:
- International Journal of Cancer therapy and oncology Journal website
- Volume:
- 5
- Issue:
- 1
- Pages:
- Article: 14
- Publication date:
- 2017-12-10
- Acceptance date:
- 2017-10-10
- DOI:
- Pubs id:
-
pubs:821224
- URN:
-
uri:8c3c5710-f52f-4272-8bee-83d72cd895ca
- UUID:
-
uuid:8c3c5710-f52f-4272-8bee-83d72cd895ca
- Local pid:
- pubs:821224
- Paper number:
- 1
- Copyright holder:
- Huang et al.
- Copyright date:
- 2017
- Notes:
- © the Author(s). This work is licensed under a Creative Commons Attribution 3.0 License.
Journal article
The efficacy of the Quercetin analogue LY294002 in immortalized cancer cell lines is related to the oxygenic and metabolic status of cells
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