Journal article
The efficacy of the Quercetin analogue LY294002 in immortalized cancer cell lines is related to the oxygenic and metabolic status of cells
- Abstract:
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Purpose: LY294002, a promising drug for chemotherapy, suppresses the activity of Phosphatidylinositol 3-Kinase (PI3K) which is pivotal to a number of processes such as proliferation, metabolism, and apoptosis. The compound has, however, been seen to have very variable efficacy in vivo.
Methods: Proliferation and viability of two immortalized cells with divergent bioenergetic profiles was determined using crystal violet staining, and the 3-(...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.0MB)
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- Publisher copy:
- 10.14319/ijcto.51.14
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Authors
Bibliographic Details
- Publisher:
- International Journal of Cancer Therapy and Oncology Publisher's website
- Journal:
- International Journal of Cancer therapy and oncology Journal website
- Volume:
- 5
- Issue:
- 1
- Article number:
- 14
- Publication date:
- 2017-12-10
- Acceptance date:
- 2017-10-10
- DOI:
- Source identifiers:
-
821224
Item Description
Terms of use
- Copyright holder:
- Huang et al
- Copyright date:
- 2017
- Notes:
- © the Author(s). This work is licensed under a Creative Commons Attribution 3.0 License.
- Licence:
- CC Attribution (CC BY)
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