Purpose: LY294002, a promising drug for chemotherapy, suppresses the activity of Phosphatidylinositol 3-Kinase (PI3K) which is pivotal to a number of processes such as proliferation, metabolism, and apoptosis. The compound has, however, been seen to have very variable efficacy in vivo.
Methods: Proliferation and viability of two immortalized cells with divergent bioenergetic profiles was determined using crystal violet staining, and the 3-(...Expand abstract
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- Peer reviewed
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- International Journal of Cancer Therapy and Oncology Publisher's website
- International Journal of Cancer therapy and oncology Journal website
- Article: 14
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- Copyright holder:
- Huang et al.
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- © the Author(s). This work is licensed under a Creative Commons Attribution 3.0 License.
The efficacy of the Quercetin analogue LY294002 in immortalized cancer cell lines is related to the oxygenic and metabolic status of cells
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