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The efficacy of the Quercetin analogue LY294002 in immortalized cancer cell lines is related to the oxygenic and metabolic status of cells

Abstract:

Purpose: LY294002, a promising drug for chemotherapy, suppresses the activity of Phosphatidylinositol 3-Kinase (PI3K) which is pivotal to a number of processes such as proliferation, metabolism, and apoptosis. The compound has, however, been seen to have very variable efficacy in vivo.

Methods: Proliferation and viability of two immortalized cells with divergent bioenergetic profiles was determined using crystal violet staining, and the 3-(...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.14319/ijcto.51.14

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
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Publisher:
International Journal of Cancer Therapy and Oncology Publisher's website
Journal:
International Journal of Cancer therapy and oncology Journal website
Volume:
5
Issue:
1
Pages:
Article: 14
Publication date:
2017-12-10
Acceptance date:
2017-10-10
DOI:
Pubs id:
pubs:821224
URN:
uri:8c3c5710-f52f-4272-8bee-83d72cd895ca
UUID:
uuid:8c3c5710-f52f-4272-8bee-83d72cd895ca
Local pid:
pubs:821224
Paper number:
1

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