- Abstract:
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Topoisomerase 2α (Topo2α) is an essential protein with DNA decatenating enzymatic properties, indispensable for chromosome decatenation and segregation. It is a target for a plethora of antitumour drugs and Topo2α protein levels have been associated with the success of treatment, but also drug resistance and secondary malignancies. Although unique in its ability to resolve catenated chromosomes, the role of Topo2α in other steps of DNA metabolism, such as DNA replication elongation and ter...
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- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
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uuid:8c2399d3-5cca-4c50-b1ca-8a5b96890f83
- Local pid:
- ora:5841
- Copyright holder:
- Diana Muftic
- Copyright date:
- 2011
Thesis
The role of Topoisomerase II in replication in mammalian cells
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