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The role of Topoisomerase II in replication in mammalian cells

Abstract:

Topoisomerase 2α (Topo2α) is an essential protein with DNA decatenating enzymatic properties, indispensable for chromosome decatenation and segregation. It is a target for a plethora of antitumour drugs and Topo2α protein levels have been associated with the success of treatment, but also drug resistance and secondary malignancies. Although unique in its ability to resolve catenated chromosomes, the role of Topo2α in other steps of DNA metabolism, such as DNA replication elongation and ter...

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Institution:
University of Oxford
Department:
Medical Sciences Division

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Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:8c2399d3-5cca-4c50-b1ca-8a5b96890f83
Local pid:
ora:5841

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