Delineation of meiotic gene expression in male mice

Thesis

Meiosis is a specialised cell division producing the haploid gametes required for sexual reproduction. A key function of this process is to generate genetic diversity through recombination and independent assortment of homologous chromosomes. Delineation of gene expression during this process has been challenging due to the heterogeneity of testis tissue and the lack of faithful in vitro models.

Here we jointly analyse a single-cell resolution transcriptomic dataset of ove...

Expand abstract

Authors: Wells, DJ

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: epigenetics; single cell RNAseq; testis; meiosis; ZCWPW1; spermatogenesis
• Subjects: functional genomics; meiosis