Thesis
Optogenetics to model activity-dependent neurodegeneration in amyotrophic lateral sclerosis
- Abstract:
-
Amyotrophic lateral sclerosis (ALS) is characterised by progressive loss of motor neurons (MNs). Increasing evidence suggests that abnormal activity and excitotoxicity may underlie the selective vulnerability of these cells. The C9ORF72 hexanucleotide repeat expansion (HRE) is the leading genetic cause, linked to early hyper- and late hypo- excitability in induced pluripotent stem cell (IPSC)-MNs. However, whether changes in activity drive MN neurodegeneration is not known. To answer this que...
Expand abstract
Actions
Authors
Contributors
+ Dafinca, R
- Role:
- Supervisor
- ORCID:
- 0000-0003-0776-6431
+ Talbot, K
- Role:
- Supervisor
- ORCID:
- 0000-0001-5490-1697
+ Akerman, C
- Role:
- Supervisor
- ORCID:
- 0000-0001-6844-4984
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Funding agency for:
- Farrimond, LE
- Grant:
- 102176/B/13/Z
- Programme:
- Wellcome Trust Doctoral Training Fellowship
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Pubs id:
-
2328916
- Local pid:
-
pubs:2328916
- Deposit date:
-
2025-10-23
- ARK identifier:
Terms of use
- Copyright holder:
- Lucy Elizabeth Farrimond
- Copyright date:
- 2024
If you are the owner of this record, you can report an update to it here: Report update to this record