Thesis
Characterisation of AQP4-specific monoclonal antibodies in neuromyelitis optica spectrum disorders
- Abstract:
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Neuromyelitis optica spectrum disorders (NMOSD) is among a small but growing group of inflammatory conditions of the central nervous system (CNS) associated with autoantibodies of the IgG class against aquaporin-4 (AQP4), a principal water channel protein in astrocytes. Activation of the classical complement pathway by AQP4-IgG has been thought to initiate the formation of NMOSD lesions. However, clinical and histopathological data suggest the existence of AQP4-IgM and its potential contri...
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- Files:
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(Preview, Dissemination version, pdf, 56.2MB, Terms of use)
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Authors
Contributors
+ Waters, P
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Clinical Neurosciences
- Research group:
- Oxford Autoimmune Neurology Group
- Role:
- Supervisor
+ Irani, S
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Clinical Neurosciences
- Research group:
- Oxford Autoimmune Neurology Group
- Role:
- Supervisor
+ Anthony, D
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Research group:
- Experimental Neuropathology Group
- Role:
- Supervisor
+ Leite, M
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Clinical Neurosciences
- Role:
- Examiner
- ORCID:
- 0000-0002-4277-9855
+ Huda, S
- Role:
- Examiner
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
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2025-03-30
- ARK identifier:
Terms of use
- Copyright holder:
- Halwan Fuad Bayuangga
- Copyright date:
- 2024
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