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Retinitis pigmentosa GTPase regulator gene replacement - a potential treatment for x-linked retinitis pigmentosa

Abstract:

X-linked retinitis pigmentosa (XLRP) is the most severe form of retinitis pigmentosa, a neurodegenerative, blinding disorder of the retina. 70% of XLRP cases are due to mutations in the retina-specific isoform of the gene encoding retinitis pigmentosa GTPase regulator (RPGRORF15). Because of the relatively large prevalence and severe clinical phenotype, the responsible gene locus, RPGRORF15, is ideally suited for a tailored gene therapeutic approach....

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Department:
Nuffield Laboratory of Ophthalmology, University of Oxford

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Department:
Nuffield Laboratory of Ophthalmology, University of Oxford
Role:
Supervisor
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Grant:
MR/K003690/1
Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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