Thesis
Retinitis pigmentosa GTPase regulator gene replacement - a potential treatment for x-linked retinitis pigmentosa
- Abstract:
-
X-linked retinitis pigmentosa (XLRP) is the most severe form of retinitis pigmentosa, a neurodegenerative, blinding disorder of the retina. 70% of XLRP cases are due to mutations in the retina-specific isoform of the gene encoding retinitis pigmentosa GTPase regulator (RPGRORF15). Because of the relatively large prevalence and severe clinical phenotype, the responsible gene locus, RPGRORF15, is ideally suited for a tailored gene therapeutic approach....
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Authors
Contributors
+ MacLaren, R
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
-
uuid:8b13dfb2-13e6-47c1-a179-16e890f8b830
- Deposit date:
- 2016-06-11
Terms of use
- Copyright holder:
- Fischer, M; M Dominik Fischer
- Copyright date:
- 2015
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