Thesis
Hypoxia related function in human osteoarthritic cartilage
- Abstract:
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Articular cartilage is an avascular tissue, and therefore, at least in large animals, functions in a hypoxic environment. In healthy human cartilage, chondrocytes exhibit a well-adapted hypoxic response. Previous work in our laboratory has shown that hypoxia in healthy human articular chondrocytes (HACs) increases anabolic function (SOX9, COL2A1, ACAN) via HIF-2α and decreases catabolism (reducing MMP13 and ADAMTS5) predominantly via HIF-1α. Inhibition of HIF-targeting hydroxylase PHD2 was...
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
-
uuid:8af7f4fd-82fc-45f5-96bf-bd4d7e511978
- Deposit date:
- 2019-10-25
Terms of use
- Copyright holder:
- Hipkiss, L
- Copyright date:
- 2018
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