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Hypoxia related function in human osteoarthritic cartilage

Abstract:

Articular cartilage is an avascular tissue, and therefore, at least in large animals, functions in a hypoxic environment. In healthy human cartilage, chondrocytes exhibit a well-adapted hypoxic response. Previous work in our laboratory has shown that hypoxia in healthy human articular chondrocytes (HACs) increases anabolic function (SOX9, COL2A1, ACAN) via HIF-2α and decreases catabolism (reducing MMP13 and ADAMTS5) predominantly via HIF-1α. Inhibition of HIF-targeting hydroxylase PHD2 was...

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Division:
MSD
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:8af7f4fd-82fc-45f5-96bf-bd4d7e511978
Deposit date:
2019-10-25

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