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Role of MukBEF in Escherichia coli chromosome organization

Abstract:

In E. coli cells, spatial chromosome organization reflects the genetic map, with the origin located at mid-cell and left and right replichores in either cell half. In contrast to the eukaryotic cell cycle, chromosome segregation occurs progressively as replication proceeds. The highly conserved SMC complex, MukBEF, plays a central role in chromosome organization and segregation, with null mutants having temperature sensitive growth and mispositioned chromosomal regions. However, d...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
David Sherratt
Oxford college:
Linacre College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:8abe7a64-cf7d-433a-9165-0ca2ced915b6
Deposit date:
2016-11-15

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