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Thesis

Ameliorating β-thalassaemia by manipulating expression of the α-globin gene

Abstract:

β-Thalassaemia is a disorder of haemoglobin production characterised by severe anaemia requiring life-long blood transfusions. The common genetic defects are predominantly based in and around the β-globin gene resulting in reduced or absent β-globin chain synthesis. The resultant excess of free α-globin chains, which precipitates in red blood cells and their precursors and causes ineffective erythropoiesis, is the main pathophysiological mechanism of anaemia in these patients. Clinical and...

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Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Department:
University of Oxford
Role:
Author

Contributors

Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:8ab09cca-83a0-459d-9e2f-333051e474de
Deposit date:
2016-04-04

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