Thesis
Genetic and molecular basis of myeloid neoplasms at single cell resolution
- Abstract:
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Myeloproliferative neoplasms (MPN) originate in a single human haematopoietic stem cell which acquires a somatic mutation and undergoes clonal expansion. This initial clone usually accumulates further genetic lesions during disease progression, giving rise to a genetically heterogeneous population of tumour cells, which are also molecularly and functionally distinct. This makes it challenging to effectively target all cancer cells in a particular patient, and as a consequence, currently a...
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- Files:
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(Preview, Dissemination version, pdf, 22.9MB, Terms of use)
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Authors
Contributors
+ Mead, A
- Role:
- Supervisor
- ORCID:
- 0000-0001-8522-1002
+ Jacobsen, S
- Role:
- Supervisor
+ Higgs, D
- Role:
- Examiner
- ORCID:
- 0000-0003-3579-8705
+ Gottgens, B
- Role:
- Examiner
+ Cancer Research UK
More from this funder
- Funder identifier:
- http://dx.doi.org/10.13039/501100000289
- Funding agency for:
- Rodriguez Meira, A
- Grant:
- C5255/A20936
- Programme:
- CRUK Oxford Centre DPhil Prize Studentship
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Pubs id:
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2035322
- Local pid:
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pubs:2035322
- Deposit date:
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2021-06-24
- ARK identifier:
Terms of use
- Copyright holder:
- Rodriguez Meira, A
- Copyright date:
- 2019
- Notes:
-
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