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Thesis

Genetic and molecular basis of myeloid neoplasms at single cell resolution

Abstract:

Myeloproliferative neoplasms (MPN) originate in a single human haematopoietic stem cell which acquires a somatic mutation and undergoes clonal expansion. This initial clone usually accumulates further genetic lesions during disease progression, giving rise to a genetically heterogeneous population of tumour cells, which are also molecularly and functionally distinct. This makes it challenging to effectively target all cancer cells in a particular patient, and as a consequence, currently a...

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Division:
MSD
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0001-8522-1002
Role:
Supervisor
Role:
Examiner
ORCID:
0000-0003-3579-8705
Role:
Examiner
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Name:
Cancer Research UK
Funder identifier:
http://dx.doi.org/10.13039/501100000289
Funding agency for:
Rodriguez Meira, A
Grant:
C5255/A20936
Programme:
CRUK Oxford Centre DPhil Prize Studentship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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