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Thesis

Physiological investigation of causal genetic variants in metabolic disease

Abstract:

Type 2 diabetes (T2D) is a leading cause of morbidity and mortality. Understanding the molecular pathways that regulate glucose control and weight regulation may help predict disease course and develop novel interventions to improve health outcomes. In this thesis, I use naturally occurring genetic variation in combination with physiological tests to interrogate molecular pathways implicated in metabolic disease. Specifically, I examine impact of T2D risk alleles in peptidylglycine alpha-a...

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Division:
MSD
Department:
RDM
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Supervisor
ORCID:
0000-0003-1205-1844
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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