Thesis
The causal relevance of body composition to disease: analyses of the UK Biobank and the FinnGen Study
- Abstract:
-
Background
BMI is the most commonly used measure of adiposity and body composition, but it does not differentiate between fat mass (FM) and fat-free mass (FFM). The primary aim of this thesis was to assess the causal relevance of FM and FFM to a wide range of diseases, using Mendelian randomisation (MR) methods. A secondary aim was to identify proteins with the potential to be targets of drugs for adiposity reduction.
Methods
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Authors
Contributors
+ Lacey, B
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Nuffield Department of Population Health
- Role:
- Supervisor
- ORCID:
- 0000-0003-0139-2934
+ Lewington, S
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Nuffield Department of Population Health
- Role:
- Supervisor
- ORCID:
- 0000-0002-4496-4771
+ Massa, M
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDORMS
- Sub department:
- Centre for Statistics in Medicine
- Role:
- Supervisor
- ORCID:
- 0000-0003-3205-6706
+ Bennett, D
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Nuffield Department of Population Health
- Role:
- Supervisor
- ORCID:
- 0000-0002-9170-8447
+ Nuffield Department of Population Health, University of Oxford
More from this funder
- Funding agency for:
- Orešković, T
- Programme:
- NDPH DPhil Studentship
+ Public Scholarship, Development, Disability, and Maintenance Fund of the Republic of Slovenia
More from this funder
- Funding agency for:
- Orešković, T
- Programme:
- Ad futura PhD Scholarship
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Pubs id:
-
2129301
- Local pid:
-
pubs:2129301
- Deposit date:
-
2025-05-15
- ARK identifier:
Terms of use
- Copyright holder:
- Tin Orešković
- Copyright date:
- 2024
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