Thesis icon

Thesis

The causal relevance of body composition to disease: analyses of the UK Biobank and the FinnGen Study

Abstract:

Background

BMI is the most commonly used measure of adiposity and body composition, but it does not differentiate between fat mass (FM) and fat-free mass (FFM). The primary aim of this thesis was to assess the causal relevance of FM and FFM to a wide range of diseases, using Mendelian randomisation (MR) methods. A secondary aim was to identify proteins with the potential to be targets of drugs for adiposity reduction.


Methods

Foll...

Expand abstract

Actions

  • Cite

  • Print

Authors

More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Big Data Institute - NDPH
Oxford college:
Balliol College
Role:
Author
ORCID:
0000-0001-7526-6151

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Supervisor
ORCID:
0000-0003-0139-2934
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Supervisor
ORCID:
0000-0002-4496-4771
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Supervisor
ORCID:
0000-0003-3205-6706
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Supervisor
ORCID:
0000-0002-9170-8447

More from this funder
Funding agency for:
Orešković, T
Programme:
NDPH DPhil Studentship

DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use

Views and Downloads





If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP