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Hydrogen borrowing catalysis using 1° and 2° alcohols: investigation and scope leading to α and β branched products

Abstract:

The alkylation of a variety of ketones using 1° or 2° alcohols under hydrogen borrowing catalysis is described. Initial research focused on the α-alkylation of cyclopropyl ketones with higher 1° alcohols (i.e. larger than MeOH), leading to the formation of α-branched products. Our search for additional substrates with which to explore this chemistry led us to discover that di-ortho-substituted aryl ketones were also privileged scaffolds, with Ph∗ (C6Me5) ketones being the optimal choice. Furt...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.tet.2021.132051

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
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Name:
Engineering & Physical Sciences Research Council
Grant:
EP/L023121/1
Publisher:
Elsevier
Journal:
Tetrahedron More from this journal
Volume:
86
Article number:
132051
Publication date:
2021-03-05
Acceptance date:
2021-02-19
DOI:
ISSN:
0040-4020
Language:
English
Keywords:
Pubs id:
1162422
Local pid:
pubs:1162422
Deposit date:
2021-02-19

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