Platinum-lanthanide metallodrugs for imaging and therapy

Thesis

This work describes the development of several Lanthanide-Platinum complexes and outlines the application of the products as theranostic agents. The luminescence and relaxivity properties of the complexes is investigated for imaging purposes and the cytotoxicity of the complexes is exploited for therapeutic use.

Chapter 1 discusses the fundamental properties of lanthanides and platinum. For lanthanides, the discuss focuses on their luminescence, magnetism and stability. As for platinum, the discussion focuses on the properties that relates to its cytotoxicity, such as cellular uptake. A brief literature review on Ln-Pt theronostic complexes is given.

Using the CuAAC reaction to conjugate Ln and Pt building blocks is described in Chapter 2. Another type of click reaction-SPAAC is utilised in Chapter 3. The photochemical properties of the clicked Pt complexes are studied thoroughly. The purification and characterisation of Ln-Pt complexes are also investigated.

Chapter 4 describes a series of cell-permeable Ln-Pt complexes, of which the relaxivity and cell diffusion NMR of the Gd complexes were studied and the photophysical properties of the switch-on Eu complexes was also investigated.

Chapter 5 delineates the conclusion and chapter 6 provides experimental procedures.

Authors: Yao, K

• DOI: 10.5287/ora-j1qzjbjnd
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: lanthanide-Platinum; theranostic
• Subjects: Chemistry