Thesis
Chemical tools to probe the function of TRIM33
- Abstract:
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Epigenetic modifications, including chemical modification of DNA and post-translational modifications (PTMs) to histone proteins, are important in regulating gene expression. Patterns of PTMs recruit specific recognition modules, including bromodomains, which recognise acetylated lysine residues. Bromodomains play a central role in epigenetic gene regulation and, as aberrant access to genetic information is responsible for many diseases, they are considered attractive therapeutic targets.<...
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- Files:
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(Preview, pdf, 37.8MB, Terms of use)
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Authors
Contributors
+ Conway, S
- Department:
- University of Oxford
- Role:
- Supervisor
+ McCoull, W
- Department:
- AstraZeneca
- Role:
- Supervisor
+ Engineering & Physical Sciences Research Council
More from this funder
- Funding agency for:
- Scorah, A
- Grant:
- EP/L015838/1
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- UUID:
-
uuid:89371ee9-79b5-4062-aa9e-e6cdaf374cd7
- Deposit date:
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2019-12-10
- ARK identifier:
Terms of use
- Copyright holder:
- Scorah, A
- Copyright date:
- 2019
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