The impact of age on single oocyte and their cumulus cells using single cell RNA sequencing

Thesis

Oocyte quality is the major determinant of successful fertilisation and subsequent normal embryo development. Maternal age is the greatest influencing factor limiting the success of infertility treatment. Current assisted reproductive technologies (ARTs) are unable to recover the fertility of females in two categories: pre-pubertal females who have survived cancer and older women who have delayed childbearing several years beyond their peak reproductive capacity. In the first category...

Expand abstract

Authors: Alageel, A

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: single cell RNA sequening; immature oocyte; Prepubertal oocyte; Germinal versicle; oocyte transcriptome; oocyte quality; poor oocyte quality; poor oocyte comptence; women's health; oocyte RNA; cumulus cells; oocyte senescence; ageing; oocyte ageing
• Subjects: Single cell RNA sequencing; Women's Fertility