Thesis
The biochemical properties of drug-resistant mutants of bacteria and other micro-organisms
- Abstract:
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An investigation has been made of the biochemical mechanisms of resistance to sulphonamide drugs in five strains of staphylococci. Resistant strains of micro-organisms for comparative studies are usually derived from sensitive parent organisms by a number of procedures, of which the most frequently used is repeated subcoltivation in the presence of increasing concentrations of inhibitor.
There are several possible mechanisms of drug-resistance, and some of these have been demonstrated in sulphonamide-resistant organisms. More is known about the mode of action of the sulphonamides than of most antibacterial substances, and this information directs attention to the metabolism of p-aminobenzoic acid (PAB) and folic acid, where changes seem likely to lead to the development of resistance.
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(Preview, pdf, 58.1MB, Terms of use)
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Authors
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- UUID:
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uuid:888d29b1-41c5-4c5a-8a06-3afd65f15640
- Local pid:
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polonsky:14:34
- Source identifiers:
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601870802
- Deposit date:
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2017-10-05
- ARK identifier:
Terms of use
- Copyright holder:
- White, P; White, Peter J
- Copyright date:
- 1958
- Notes:
- This thesis was digitised thanks to the generosity of Dr Leonard Polonsky
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