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Thesis

Incorporation of trehalose analogues into Mycobacterium Tuberculosis: antigen 85 and probes of bacterial infection

Abstract:

Diagnoses of tuberculosis, 'TB,' currently rely upon non-specific techniques such as X-ray exams and acid-fast microscopy. Improved diagnostics would preferably consider specific bacterial processes to provide real-time readouts of disease burden and response to chemotherapy. This dissertation presents the cell-wall incorporation of trehalose analogues (fluorescent and radioactive) by the mycobacterial antigen 85 enzymes as a novel method to label the causative bacteria of TB, Mycobac...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Oxford college:
New College
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:882d8560-c0d3-471b-a896-224a6b22a0f0
Local pid:
ora:11632
Deposit date:
2015-06-11

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