Thesis
Prediction of coronary heart disease risk using polygenic risk scores in a Mexican population
- Abstract:
-
Background: Coronary heart disease (CHD) is the global leading cause of death with a high genetic heritability and polygenic predisposition. Polygenic risk scores (PRSs) have been found to enhance CHD risk prediction in populations of European ancestry but evidence in other populations is limited.
Thesis aims: 1) To conduct a literature review on PRSs published for CHD risk prediction. 2) To evaluate the transferability of eight external CHD PRSs in t... Expand abstract
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Authors
Contributors
+ Gnatiuc Friedrichs, L
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Nuffield Department of Population Health
- Role:
- Supervisor
- ORCID:
- 0000-0002-0641-2220
+ Torres, J
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Nuffield Department of Population Health
- Role:
- Supervisor
+ Emberson, J
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Nuffield Department of Population Health
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Deposit date:
-
2025-12-03
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